| Date | Location | Result | |
| Oct 27, 2010 | Spartanburg, S.C. | ETSU 4, USC Upstate 1 | Box score |
| Oct 24, 2010 | Nashville, Tenn. | Belmont 4, USC Upstate 1 | Box score |
| Oct 22, 2010 | Nashville, Tenn. | Lipscomb 1, USC Upstate 0 | Box score |
| Oct 17, 2010 | Spartanburg, S.C. | Jacksonville 4, USC Upstate 0 | Box score |
| Oct 15, 2010 | Spartanburg, S.C. | North Florida 2, USC Upstate 1 | Box score |
| Oct 10, 2010 | DeLand, Fla. | Stetson 2, USC Upstate 1 (2OT) | Box score |
| Oct 08, 2010 | FORT MYERS, Fla. | FGCU 2, USC Upstate 0 | Box score |
| Oct 02, 2010 | Spartanburg, S.C. | Campbell 1, USC Upstate 0 | Box score |
| Sep 30, 2010 | Spartanburg, S.C. | Mercer 2, USC Upstate 0 | Box score |
| Sep 25, 2010 | Spartanburg, S.C. | Furman 0, USC Upstate 0 (2OT) | Box score |
| Sep 22, 2010 | Spartanburg, S.C. | USC Upstate 1, UNC Asheville 0 | Box score |
| Sep 17, 2010 | Spartanburg, S.C. | Wofford 4, USC Upstate 1 | Box score |
| Sep 15, 2010 | Boiling Springs, NC | Gardner-Webb 1, USC Upstate 0 | Box score |
| Sep 07, 2010 | Spartanburg, S.C. | Presbyterian College 1, USC Upstate 1 (2OT) | Box score |
| Sep 04, 2010 | Atlanta, Ga. | USC Upstate 1, Georgia State 1 (2OT) | Box score |
| Sep 01, 2010 | Statesboro, Ga. | Georgia Southern 4, USC Upstate 3 | Box score |